BioTrove and Gene Express : NIH Grant to Develop Novel Standardized Genetic Profiling Test

July 1, 2008 - BioTrove Inc. and Gene Express, Inc. announced their receipt of a two-year National Institutes of Health (NIH) grant, awarded in support of their proposed novel research of genetic biomarkers for lung cancer.
Part of the NIH competitive grant program "Innovative Technologies for Molecular Analysis of Cancer," the project will combine for the first time BioTrove's OpenArray™ nanofluidic polymerase chain reaction (PCR) technology platform, Gene Express standards for accurate and consistent PCR measurement, and the clinical expertise of the Mount Sinai School of Medicine, with the goal of creating a standardized genetic profiling test for indicators of lung cancer risk.

The exciting thing about this project is that we are combining proven PCR technologies and existing genetic knowledge to create a new tool with the potential to significantly impact patient care and treatment options for this deadly disease.. BioTrove's Press Release -

Gene Express : licensing agreement with University of South Florida

04.21.08 - Gene Express, Inc. announced that it has signed an agreement with the Division of Patents & Licensing Research Office at the University of South Florida (USF) to license some of their gene expression technology necessary to develop prognostic tests for cisplatin and irinotecan chemoresistance.

The ability to assess patients for resistance to chemotherapeutics prior to chemotherapy would offer physicians an important tool in providing appropriate chemotherapy to patients afflicted with cancers of the lung and colon. Mechanisms of chemoresistance likely involve multiple gene products involved in DNA repair, drug uptake and other unspecified processes... Gene Express' Press Release -

Gene Express, Lung Cancer Diagnostic

September 27, 2007) - Gene Express, Inc. today announced that its molecular diagnostic test for lung cancer has demonstrated high levels of accuracy in a recent study presented at the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development... To determine which genes are active in lung cancer, Dr. Willey and his colleagues utilized Gene Express's proprietary and patented StaRT-PCR™ (Standardized Reverse Transcription Polymerase Chain Reaction) platform technology for measuring messenger RNA (mRNA) transcripts levels of the 15 genes... Gene Express' press Release -