MAP Pharmaceuticals : Positive Results From Comparative Pharmacokinetic Trial for its Pediatric Asthma Product Candidate

March 24, 2008 - MAP Pharmaceuticals, Inc. (Nasdaq: MAPP) announced that in a pharmacokinetic clinical trial Unit Dose Budesonide (UDB) demonstrated lower systemic drug exposure when compared to the currently marketed conventional nebulized budesonide. UDB is MAP Pharmaceuticals' proprietary nebulized formulation of budesonide, currently in Phase 3 clinical development, for the potential treatment of pediatric asthma. UDB is designed to be administered more quickly and to provide efficacy at lower doses than conventional nebulized budesonide, which is the current leading treatment for pediatric asthma.

The clinical trial was a randomized, open label, cross-over study evaluating the pharmacokinetic profile of two doses of UDB given twice daily in 32 adults with mild to moderate asthma. A 0.135 mg dose of UDB was compared as an alternative to a 0.25 mg dose of conventional nebulized budesonide given twice daily, and a 0.25 mg dose of UDB was compared as an alternative to a 0.5 mg dose of conventional nebulized budesonide given twice daily... MAP Pharmaceuticals ' Press Release -

MAP Pharmaceuticals, Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma

Oct 31, 2007 - ...MAP0005 is a combination of a corticosteroid and a long-acting beta2-agonist delivered to the respiratory tract using MAP Pharmaceuticals' Tempo(TM) inhaler. MAP0005 uses the Company's proprietary particle technology to combine the corticosteroid and beta-agonist components into a single drug particle in a fixed, pre-specified ratio. In addition, MAP Pharmaceuticals' technology allows for the particle structure to be specifically designed to target relevant areas in the lung and to release drug at a desired rate. MAP Pharmaceuticals believes that this approach may enable the reproducible and consistent administration of the two drugs in an optimal ratio simultaneously, and may provide improved safety and efficacy over currently available combination therapies for asthma and COPD... MAP Pharmaceuticals' Press Release -